Database Technical Assistance - 340B Prime Vendor Program - Apexus

340B Database Technical Assistance


The 340B Office of Pharmacy Affairs Information System (OPAIS) is the official list of covered entities eligible to purchase or use 340B drugs for its patients.  The 340B OPAIS provides the most current information HRSA has on participating covered entities, contract pharmacy arrangements, and drug manufacturers.  In addition, the 340B OPAIS signals whether covered entities bill Medicaid for 340B drugs.  The 340B OPAIS gives manufacturers and wholesalers positive assurance that the purchasing/receiving site is eligible to obtain 340B drugs. 

Click here to access the 340B OPAIS, change request forms, reports, and other useful information. Newly registered covered entities become active in the 340B database at the start of a new quarter:  January 1, April 1, July 1, and October 1.  HRSA strives to complete processing of new registrations and terminations no later than two weeks prior to the start of each quarter; changes to existing covered entity records are processed as received throughout the year.  It is the covered entity's responsibility to the keep the record accurate and up to date.  

Click here for the 340B OPAIS Public User Guide

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