340B Prime Vendor Program

Public Health Emergency Declaration by the Secretary

HRSA recognizes that circumstances surrounding disaster relief efforts warrant flexibility for entities eligible for participation in the 340B Program.

Therefore, eligible entities in Florida, Georgia, Louisiana, North Carolina, Puerto Rico, and South Carolina may immediately enroll for the 340B Program during the Public Health Emergency Declaration by the Secretary, rather than having to wait for the normal quarterly registration period.

We believe this will enable these entities to meet the needs of the residents affected by this disaster. If you are in the listed states/territories and would like to enroll, email the 340B Prime Vendor Program or call 1.888.340.2787.

Become a 340B Participant

The registration component of the 340B Office of Pharmacy Affairs Information System (340B OPAIS) is now available.

Information regarding flexibilities allowed during a Public Health Emergency Declaration by the Secretary is available here.

New registrations are accepted October 1-15,
January 1-15, April 1-15 and July 1-15.


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