Due to an unusually high volume of COVID-19 related calls, it may take longer than usual to reach a call center specialist. Your call is important to us. For general inquiries, we request that all stakeholders review the information on a new webpage created specifically for issues related to the COVID-19 pandemic and its impact on the 340B Program.


To the extent a 340B stakeholder has a specific circumstance where they believe their COVID-19 response may affect their compliance or eligibility in the 340B Program, the stakeholder should contact the 340B Prime Vendor at 1.888.340.2787 (Monday – Friday, 8 a.m. – 5 p.m. CT) or apexusanswers@340bpvp.com. The 340B Prime Vendor will coordinate with HRSA technical assistance and evaluate each issue on a case-by-case basis.

Become a 340B Participant

The registration component of the 340B Office of Pharmacy Affairs Information System (340B OPAIS) is now available.

Information regarding flexibilities allowed during a Public Health Emergency Declaration by the Secretary is available here.

New registrations are accepted October 1-15,
January 1-15, April 1-15 and July 1-15.


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